# Caloric restriction and cardiovascular

1 paper in the library, strongest Strong.

**Graded Strong**: Randomized controlled trial in 185 healthy adults over 2 years, with effects holding at both 12 and 24 months, though outcomes are biomarker-based organ ages in a subset of the full trial.

## Papers (1)

- [Caloric Restriction Slows Aging Most in the Heart and Metabolism](https://longevity-germany.com/en/research/caloric-restriction-slows-aging-most-in-the-heart-and-metabolism) · Strong · n = 185 · 2026 · Clinical nutrition (Edinburgh, Scotland)

## How this map is computed

A mark's size is the number of papers we hold on that pairing. It is a count, not a weighting by study design or sample size.

The fill shows the strongest grade in the cell. One Strong paper among four Preliminary ones still fills it dark, so open the cell to see the rest.

Grades and verdicts are assigned by a named person, never by counting.

An empty cell is a finding: nobody in our library has run that trial yet.

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_Canonical: https://longevity-germany.com/en/evidence/caloric-restriction/cardiovascular · Part of Longevity Cities_