# Advanced glycation end-products (AGEs)

Advanced glycation end-products are stable, often crosslinked compounds formed when sugars react with proteins, lipids, or DNA over time. They accumulate in long-lived tissues such as skin, cartilage, and arterial walls, where they impair elasticity and function. AGEs activate the RAGE receptor, triggering inflammation and oxidative stress. Their build-up is linked to diabetes complications, atherosclerosis, kidney disease, and skin ageing.

## Sources

- Bierhaus A, Humpert PM, Morcos M, et al.. (2005). Understanding RAGE, the receptor for advanced glycation end products. Journal of Molecular Medicine. https://doi.org/10.1007/s00109-005-0688-7
- Brownlee M. (2001). Biochemistry and molecular cell biology of diabetic complications. Nature. https://doi.org/10.1038/414813a

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