# GGT (Gamma-glutamyl transferase)

Gamma-glutamyl transferase (GGT) is a membrane-bound enzyme that transfers gamma-glutamyl groups and supports glutathione recycling, with highest activity in liver, biliary epithelium, and kidney. Serum GGT rises with cholestasis, alcohol intake, hepatic steatosis, and many enzyme-inducing drugs, making it a sensitive but unspecific liver marker. Beyond hepatology, higher GGT within the reference range is independently associated with insulin resistance, cardiovascular disease, and increased all-cause mortality, marking oxidative stress.

## Sources

- Targher G. (2010). Elevated serum gamma-glutamyltransferase activity is associated with increased risk of mortality, incident type 2 diabetes, cardiovascular events, chronic kidney disease and cancer — a narrative review. Clinical Chemistry and Laboratory Medicine. https://doi.org/10.1515/CCLM.2010.031
- Kunutsor SK, Apekey TA, Cheung BMY. (2015). Gamma-glutamyltransferase and risk of hypertension: a systematic review and dose-response meta-analysis of prospective evidence. Journal of Hypertension. https://doi.org/10.1097/HJH.0000000000000763

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_Canonical: https://longevity-germany.com/en/glossary/ggt · Part of Longevity Cities · Updated 2026-05-07_