# HOMA-IR

HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a fasting blood index calculated as (fasting insulin in µU/mL × fasting glucose in mmol/L) / 22.5, or equivalently (fasting insulin in µU/mL × fasting glucose in mg/dL) / 405. It estimates whole-body insulin resistance from fasting measures, predominantly reflecting hepatic insulin action, as a low-cost surrogate for clamp methods. Cutoffs are population- and assay-dependent, with no universal threshold; values are commonly cited roughly between 1.5 and 2.9 in adults depending on population and assay, with no consensus value.

## Sources

- Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. (1985). Homeostasis Model Assessment: Insulin Resistance and Beta-Cell Function from Fasting Plasma Glucose and Insulin Concentrations in Man. Diabetologia. https://doi.org/10.1007/BF00280883

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_Canonical: https://longevity-germany.com/en/glossary/homa-ir · Part of Longevity Cities · Updated 2026-05-02_