# Hyperbaric oxygen therapy (HBOT)

Hyperbaric oxygen therapy delivers 100% oxygen at pressures typically of 2.0–2.4 atmospheres absolute (with the clinical threshold for HBOT generally defined as at least 1.4 ATA) inside a pressurised chamber, dramatically increasing dissolved oxygen in plasma. It is an established treatment for decompression sickness, carbon monoxide poisoning, and selected non-healing wounds. Off-label longevity uses (telomere length, cognition, anti-ageing) rely on small trials with methodological limits; current evidence does not support routine use for healthy ageing.

## Sources

- Hachmo Y, Hadanny A, Abu Hamed R, et al.. (2020). Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. Aging (Albany NY). https://doi.org/10.18632/aging.202188

---

_Canonical: https://longevity-germany.com/en/glossary/hyperbaric-oxygen-therapy · Part of Longevity Cities · Updated 2026-01-15_