# Quercetin

Quercetin is a flavonoid abundant in onions, apples, capers, and berries with antioxidant and anti-inflammatory activity. It is investigated as a senolytic, though standalone activity is inconsistent in human cell models; the combination with dasatinib (D+Q) is the regimen actually studied in early human senolytic trials. Standalone supplementation has shown small, inconsistent blood pressure effects mainly in hypertensive populations, and bioavailability is low. Human anti-aging evidence is preliminary.

## Sources

- Justice JN, Nambiar AM, Tchkonia T, et al.. (2019). Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study. EBioMedicine. https://doi.org/10.1016/j.ebiom.2018.12.052

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