# A Better-Absorbed Niacinamide and CoQ10 Gel Improved Skin in 12 Weeks

*Niacinamide/ Co-enzyme Q10 loaded transferosomal gel for anti-aging and enhanced biophysical skin outcome: a split-face clinical study.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article
- **Journal**: Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology
- **Sample Size**: Healthy female volunteers (split-face study)
- **Authors**: Zafar T, Shoaib Khan HM, Jamil QA, Ijaz S
- **Published**: 2026-07-05
- **Topics**: skin aging, CoQ10, niacinamide
- **DOI**: https://doi.org/10.1080/14764172.2026.2698114
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42402180/

## Summary

Women used a face gel with niacinamide and CoQ10 built for deeper skin penetration. Compared to a plain gel, it did more for hydration, elasticity, spots, and wrinkles. Some benefits showed up as early as two weeks. The trick was the delivery method, not just the ingredients.

## Practical Takeaway

This study suggests how a skincare product is delivered may matter as much as its ingredients.

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