# B12 Pills, Drops or Shots All Raise Levels, but None Proven Better for Symptoms

_Evidence Level: Preliminary · Cohen RV et al., EClinicalMedicine, DOI 10.1016/j.eclinm.2026.104205_

*Vitamin B12 replacement strategies: a Brazilian delphi consensus.*

- **Evidence Level**: Preliminary
- **Why this grade**: Delphi consensus of 20 experts informed by a review, yet it reflects opinion rather than new trial data and was funded by a B12 maker.
- **Facts**: Funding: Myralis Indústria Farmacêutica Ltda
- **Publication Types**: Journal Article
- **Journal**: EClinicalMedicine
- **Sample Size**: 20 Brazilian medical experts
- **Authors**: Cohen RV, Levinson R, Baiocchi O, Salles JEN, Cavalcante França M, Navarro T, Trujilho F, Soares JM, Nakagawa D, Valente M, Barbuti R, Spera RR, Moura F, Valerio C, Schiavon CA, Dos Santos FC, Batista Dantas AC, Abdo A, Steiner ML, Korkes HA, Cordenonssi JT, Bachour P
- **Graded and published**: 2026-09-23
- **Last edited**: 2026-10-07
- **Topics**: Vitamin B12, Supplements
- **DOI**: https://doi.org/10.1016/j.eclinm.2026.104205
- **Free full text**: https://pmc.ncbi.nlm.nih.gov/articles/PMC13634271/
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42830915/

## Summary

Pills, under-the-tongue tablets and injections all bring vitamin B12 blood levels back up. But no form has been shown to beat the others for symptoms, nerve recovery or quality of life. A panel of 20 Brazilian experts reached this view by voting on statements drawn from a review of existing research. This is expert opinion funded by a B12 maker, and solid long-term trials comparing the forms are still missing.

## Practical Takeaway

This consensus suggests the cause of a B12 deficiency may matter more than the form used.

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_Canonical: https://longevity-germany.com/en/research/b12-pills-drops-or-shots-all-raise-levels-but-none-proven-better-for-symptoms · Part of Longevity Cities · Updated 2026-10-07_