# Cardio or Senolytics May Keep Aging Hearts Working Better, a Mouse Study Finds

_Evidence Level: Preliminary · Bevington RT et al., Aging cell, DOI 10.1111/acel.70759_

*Chronic Senolytic Treatment and/or Aerobic Exercise Reduce Senescence and Improve Myocardial Function During Aging in the Heart.*

- **Evidence Level**: Preliminary
- **Why this grade**: Randomized study in 54 middle-aged mice over nine months, yet animal results may not carry over to people.
- **Facts**: Duration: 8 months · Funding: Natural Sciences and Engineering Research Council of Canada; CIHR
- **Population**: Animal study
- **Publication Types**: Journal Article
- **Journal**: Aging cell
- **Sample Size**: 54 middle-aged male and female mice
- **Authors**: Bevington RT, Johnson AL, Hockey BL, Fajardo VA, Parise G
- **Graded and published**: 2026-10-01
- **Last edited**: 2026-10-09
- **Topics**: Senolytics, Exercise, Heart Health
- **DOI**: https://doi.org/10.1111/acel.70759
- **Free full text**: https://pmc.ncbi.nlm.nih.gov/articles/PMC13644388/
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42841582/

## Summary

Long-term cardio and the senolytic combo dasatinib plus quercetin each cut the number of worn-out zombie cells in aging mouse hearts. Mice got nine months of treatment starting in middle age, and both approaches helped their hearts relax and pump better. For anyone who does regular cardio, this hints that exercise may rival a drug here, though combining both gave no reported extra boost. This was only in mice, and whole-heart aging and inflammation markers did not change with any treatment.

## Practical Takeaway

This mouse study suggests long-term aerobic exercise may support healthier heart aging.

---

_Canonical: https://longevity-germany.com/en/research/cardio-or-senolytics-may-keep-aging-hearts-working-better-a-mouse-study-finds · Part of Longevity Cities · Updated 2026-10-09_