# High-Dose DHA Reaches the Brain but Didn't Boost Memory in 2 Years

*CNS target engagement of high-dose DHA supplementation in older adults at risk for dementia: a randomised, double-blind, placebo-controlled trial.*

- **Evidence Level**: Strong
- **Publication Types**: Journal Article
- **Journal**: EBioMedicine
- **Sample Size**: 365 adults aged 55-80 at risk for dementia
- **Authors**: Yassine HN, Pour SG, Juarez M, Arrelanas IC, Ali N, Dikeman D, Sanchez A, Park J, Kerman B, Duro MV, Asante I, Louie S, Kono N, D'Orazio LM, Chui H, Mack WJ, Harrington MG, Braskie MN, Schneider LS
- **Published**: 2026-06-18
- **Topics**: omega-3, DHA, brain health, dementia
- **DOI**: https://doi.org/10.1016/j.ebiom.2026.106316
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42315445/

## Summary

Omega-3 DHA is a popular pick for brain health, especially for people at risk of dementia. This two-year trial gave older adults with low omega-3 intake high-dose DHA. The DHA clearly made it into their brain fluid, even in those carrying the high-risk APOE ε4 gene. But there was no difference in memory, thinking, or brain size compared to placebo.

## Practical Takeaway

This study suggests high-dose DHA reaches the brain but may not improve memory in at-risk older adults.

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_Canonical: https://longevity-germany.com/en/research/high-dose-dha-reaches-the-brain-but-didn-t-boost-memory-in-2-years · Part of Longevity Cities · Updated 2026-06-18_