# How an Aging Immune System May Drive Alzheimer's and Parkinson's

*Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article, Review
- **Journal**: Cells
- **Sample Size**: N/A
- **Authors**: Bertoni G, Ristori S, Monti D
- **Published**: 2026-04-08
- **Topics**: neurodegeneration, inflammaging, immune aging
- **DOI**: https://doi.org/10.3390/cells15080657
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42041525/

## Summary

As we age, the immune system gets sloppy and starts running a low-grade inflammation in the background (called inflammaging). This review argues that aging immune cells in the brain lose their protective role and instead fuel diseases like Alzheimer's and Parkinson's. Researchers are exploring senolytics and microbiome therapies to calm this chronic inflammation. It's a reminder that brain aging and immune aging are deeply linked.

## Practical Takeaway

This review suggests strategies that lower chronic inflammation may help protect the aging brain.

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_Canonical: https://longevity-germany.com/en/research/how-an-aging-immune-system-may-drive-alzheimer-s-and-parkinson-s · Part of Longevity Cities · Updated 2026-04-08_