# Nicotinamide Riboside Improved Movement in Parkinson's Mice Without Saving Neurons

*Nicotinamide Riboside Enhances Mitochondrial Bioenergetics and Dopaminergic Signaling Independent of Neuron Survival in a Double-Hit Parkinson's Model.*

- **Evidence Level**: Preliminary
- **Publication Types**: Journal Article, Preprint
- **Journal**: Research square
- **Sample Size**: Mice with a double-hit Parkinson's model
- **Authors**: Saha S, Meng C, Dong J, Zhou J, Wang S, Papaneri A, Sun L, Cai H, Cui G
- **Published**: 2026-06-19
- **Topics**: nicotinamide riboside, Parkinson's, mitochondria
- **DOI**: https://doi.org/10.21203/rs.3.rs-9970859/v1
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42370283/

## Summary

Nicotinamide riboside (NR), a popular NAD-boosting supplement, improved movement in mice with a Parkinson's-like condition. It did this by boosting energy production in cells and increasing dopamine signaling, even though it did not stop brain cells from dying. So the benefit came from making the surviving cells work better, not from protecting them. This was in mice, so it's a hint at a possible add-on strategy, not proof for people.

## Practical Takeaway

This mouse study suggests NR may ease Parkinson's movement problems by boosting cell energy.

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_Canonical: https://longevity-germany.com/en/research/nicotinamide-riboside-improved-movement-in-parkinson-s-mice-without-saving-neurons · Part of Longevity Cities · Updated 2026-06-19_