# Scientists Find Universal Aging Signatures Across Mice, Monkeys, and Humans

*Universal transcriptomic hallmarks of mammalian ageing and mortality.*

- **Evidence Level**: Strong
- **Publication Types**: Journal Article
- **Journal**: Nature
- **Sample Size**: 11,000+ tissue samples across mice, rats, macaques, humans
- **Authors**: Tyshkovskiy A, Kholdina D, Davitadze M, Molière A, Moldakozhayev A, Tongu Y, Kasahara T, Glubokov D, Eames A, Kats LM, Vladimirova A, Ying K, Liu H, Zhang B, Khasanova U, Moqri M, Van Raamsdonk JM, Harrison DE, Strong R, Abe T, Dmitriev SE, Gladyshev VN
- **Published**: 2026-05-27
- **Topics**: aging biomarkers, epigenetics, longevity research
- **DOI**: https://doi.org/10.1038/s41586-026-10542-3
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42203874/

## Summary

Researchers pulled together over 11,000 gene activity samples from four mammal species to find what aging actually looks like at the molecular level. They found shared signatures across species, including two markers (CDKN1A and LGALS3) that also tracked with death risk and multiple diseases in UK Biobank data. Caloric restriction mainly slowed aging in mitochondrial pathways, while chronic diseases sped up inflammation-related aging.

## Practical Takeaway

This research is mechanistic, but it supports the idea that inflammation and mitochondrial health are key aging levers.

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