# Spermidine Cut Dry Mouth Nearly in Half for Cancer Patients After Radiation

*Oral Spermidine Supplementation Preserves Submandibular Gland Function After Radiotherapy: Mechanistic Insights and Use in a Phase II Randomized Clinical Trial.*

- **Evidence Level**: Moderate
- **Publication Types**: Journal Article
- **Journal**: MedComm
- **Sample Size**: About 58 head and neck cancer patients undergoing radiotherapy
- **Authors**: Min Y, Gao K, Liu Y, Dai L, Peng X
- **Published**: 2026-07-15
- **Topics**: spermidine, cancer, quality of life
- **DOI**: https://doi.org/10.1002/mco2.70862
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42460130/

## Summary

Radiation for head and neck cancer often wrecks the salivary glands, leaving people with a miserably dry mouth. In a small human trial, people taking spermidine during radiation had far fewer cases of dry mouth at 3 months, 48% versus 79% on placebo. Their saliva flow and quality of life improved, with no serious side effects. Mouse and lab work backed up how the supplement protects gland cells.

## Practical Takeaway

This study suggests spermidine may help protect salivary glands during head and neck radiation.

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_Canonical: https://longevity-germany.com/en/research/spermidine-cut-dry-mouth-nearly-in-half-for-cancer-patients-after-radiation · Part of Longevity Cities · Updated 2026-07-15_