# The Rare APOE2 Gene Protects the Brain by Keeping Blood Vessel Cells Clean

*The longevity gene APOE2 enhances pericyte function and reduces lipid droplets.*

- **Evidence Level**: Preliminary
- **Facts**: Design: Journal Article
- **Publication Types**: Journal Article
- **Journal**: Brain : a journal of neurology
- **Sample Size**: Humanized APOE knock-in mice plus human iPSC-derived pericyte lines
- **Authors**: Reskiawan A Kadir R, Bons J, Vega Hormazabal G, Vadhana Ashok Kumaar P, Gerónimo-Olvera C, Tshilenge KT, Pihán P, Galicia Aguirre C, Schneider K, Roberts A, Ambrose BD, Lerner C, Devanney NA, Sandholm AM, Hady M, Alderfer S, Hetz C, Furman D, Gerencser AA, Verdin E, Schilling B, Ellerby LM
- **Graded and published**: 2026-09-16
- **Topics**: APOE, brain health, Alzheimer's
- **DOI**: https://doi.org/10.1093/brain/awag311
- **Original Source**: https://pubmed.ncbi.nlm.nih.gov/42744302/

## Summary

Most people know APOE4 as the gene that raises Alzheimer's risk. Its opposite, APOE2, is linked to lower risk and longer life, and this work shows one reason why. In mice and in human stem-cell-derived cells, APOE2 kept pericytes (tiny cells that seal the blood-brain barrier) healthier, more resistant to aging, and less clogged with fat droplets. Adding APOE2 protein to APOE3 and APOE4 cells partly fixed their problems, which hints at a future drug target.

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_Canonical: https://longevity-germany.com/en/research/the-rare-apoe2-gene-protects-the-brain-by-keeping-blood-vessel-cells-clean · Part of Longevity Cities · Updated 2026-09-16_