Tracking Your 'Biological Age' Over Time May Predict Death Risk Better Than a Single Snapshot
In over 90,000 Dutch adults followed for nearly 14 years, people whose biological age ran ahead of their calendar age had a higher risk of dying. More importantly, among 25,000 people measured twice, those whose biological age sped up over time faced even greater risk. People stuck in a pattern of accelerated aging had a 39% higher mortality risk compared to those aging at a normal pace. The results suggest that checking biological age once might not be enough.
Kernaussage
This study suggests monitoring biological age over time could be more informative than a one-time measurement.
Originalstudie
Verwandte Studien
Faster Biological Aging Linked to Worsening Brain Small Vessel Disease
People who age faster biologically (based on blood biomarkers) appear more likely to develop worsening brain small vessel disease. In roughly 3,000 middle-aged adults followed for about five years, those with higher biological age scores had more new tiny brain lesions like lacunes and microbleeds. This held true even after accounting for actual calendar age. The finding suggests that biological aging clocks could help flag people at risk for this common precursor to dementia and stroke.
Centenarians Show a Distinct Metabolic Profile Tied to Bile Acids and NAD+
People who live past 100 have a unique metabolic fingerprint. In a study of 213 participants from the New England Centenarian Study, extremely long-lived individuals had higher levels of certain bile acids and lower levels of bilirubin compared to younger controls. Higher bile acid and steroid levels were linked to lower mortality risk. The researchers also built a "metabolomic clock" that estimates biological age, and deviations from it predicted death risk.
Loneliness and Social Isolation Are Linked to Faster Biological Aging
Being lonely or socially isolated is associated with measurably faster biological aging. Across over 340,000 UK Biobank participants and 6,300 NHANES participants, higher loneliness and isolation scores correlated with accelerated aging on multiple biomarker clocks. The effect was consistent across three different ways of measuring biological age. Faster biological aging also appeared to partly explain how loneliness connects to earlier death.
Haftungsausschluss: Forschungszusammenfassungen dienen nur zu Informationszwecken und stellen keine medizinische Beratung dar. Konsultiere immer einen qualifizierten Arzt, bevor du Änderungen an deiner Gesundheitsroutine vornimmst.