How a Cellular Calcium Glitch Speeds Up Aging in Mice
Based on: Ameliorating calcium homeostasis improves longevity and healthspan in progeroid and naturally aged mice.
When cells lose control of their calcium balance, it sets off a chain reaction that triggers DNA damage and inflammation tied to aging. In mice, an old antidepressant called mianserin calmed this calcium chaos. It improved several signs of aging and lengthened their lives. This points to calcium control as a possible target for slowing aging.
Key Insight
This study suggests calcium balance inside cells may be a future target for aging research.
Original Paper
Xiang W, Hu Q, Sun P, Wu X, Jiang H, Qu M, Li L, Wang Y, Wang Z, Liu X, Ma J, Zhu D, Li H, Wang Y, Jiao Y, Huang B, Lu J, Cong X, Li W, Zhang Y
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Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.