What Centenarians' Immune Systems Reveal About Escaping Age-Related Disease

Based on: The long-lived immune system of centenarians.

Moderate Evidence·Journal Article·Review·Nature reviews. Immunology·Apr 2026

People who live past 100 tend to have immune systems that look surprisingly young. This review found they have less chronic inflammation, better cellular cleanup (autophagy), and gut bacteria patterns linked to healthy aging. Those living past 110 often have immune profiles resembling much younger adults.

Key Insight

This research suggests that keeping inflammation low may be one pillar of reaching extreme old age.

Original Paper

Plaza-Florido A, Carrera-Bastos P, Pérez-Prieto I, Fiuza-Luces C, Radom-Aizik S, Del Pozo Cruz B, Franceschi C, López-Soto A, López-Otín C, Lucia A

Nature reviews. Immunology··N/A

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Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.