32 studies
Research Library
Peer-reviewed papers from top journals, summarized and graded by evidence strength. Updated Mon, Wed & Fri.
Longevity Protein Klotho May Protect Against Cognitive Decline in Parkinson's
People with Parkinson's disease who carry a specific variant of the klotho gene tended to perform better on executive thinking tasks across two separate groups. In mice engineered to model Parkinson's, boosting klotho levels improved brain function and reduced alpha-synuclein (a toxic protein that builds up in Parkinson's). The cognitive benefits showed up without improving motor symptoms. Lab experiments suggested klotho may work by helping brain cells clear that toxic protein more effectively.
Two Opposing Brain Fuel Patterns May Predict Who Keeps Their Cognition With Age
Brain white matter (the wiring that connects brain regions) uses glucose differently depending on where you look. In over 3,000 participants across two studies, higher glucose use in expected areas like the corpus callosum linked to better thinking skills. But higher glucose use in unusual areas like the corona radiata linked to worse cognition, likely a sign the brain is compensating. Over time, people with strong "normal" metabolism and low "compensatory" metabolism declined more slowly.
Worse Metabolic Syndrome Tied to Faster Cognitive Decline in Older Adults
Among Chinese adults over 60, having more severe metabolic syndrome was linked to faster mental decline over several years. The connection held for both overall cognition and memory specifically. People in the worst quarter of cumulative metabolic syndrome scores declined in memory about three times faster than those in the best quarter. These findings come from two large studies tracking participants for up to eight years.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.
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