Caloric Restriction Slows Aging Most in the Heart and Metabolism

Strong Evidence·Clinical nutrition (Edinburgh, Scotland)·Mar 2026

Cutting calories doesn't slow aging evenly across all organs. In a two-year trial, 185 adults were randomly assigned to caloric restriction or normal eating. The caloric restriction group aged about one year less in their cardiovascular and metabolic systems over 24 months. Kidney aging, however, didn't budge, and liver aging only slowed modestly at the two-year mark.

Key Insight

This study suggests caloric restriction may preferentially protect cardiovascular and metabolic health.

Original Paper

Clinical nutrition (Edinburgh, Scotland)··185 healthy adults (120 CR, 65 control)

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