Senolytic therapy

Senolytic therapy uses drugs or natural compounds to selectively eliminate senescent cells, which accumulate with age and secrete a multi-component secretome (the SASP) of inflammatory cytokines and chemokines, growth factors, and tissue-remodeling proteases such as MMPs. By targeting senescent-cell anti-apoptotic pathways (SCAPs) and promoting selective apoptosis in these cells, senolytics aim to reduce age-related dysfunction. Evidence is robust in animal models, but human trials remain small and early; clinical efficacy, optimal dosing, and long-term safety are unproven.