A Hidden Cloak Lets Zombie Cells Dodge Your Immune System
Graded Preliminary — knockout and antibody experiments in aged mice with isolated human cells, so the effects on senescent cells have not yet been tested in people.
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- NIA NIH HHS; NIDDK NIH HHS
Senescent cells (worn-out cells that stop dividing but refuse to die) pile up with age and drag down metabolism and muscle. Researchers found these cells wear a protein called PD-L2 that acts like an invisibility cloak against immune attack. Mice bred without PD-L2 had fewer zombie cells, better insulin sensitivity and stronger grip in old age. Blocking PD-L2 with a drug also restored insulin sensitivity in old mice. This is early animal work, not something available to people yet.
Conflict of Interest Disclosure: Several authors hold senolytic patents and shares in longevity biotech companies.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.