A Tiny RNA Fragment May Be Key to How Fasting Extends Lifespan
Based on: Ribonuclease DIS3 delays aging and senescence by generating tRNA halves.
Scientists found that an enzyme called DIS3 chops transfer RNAs into small pieces that help slow aging. In worms, one fragment called 5'-tRH-Gln was needed for the lifespan boost from dietary restriction. The same system delayed cell aging in mammalian cells, pointing to a shared longevity mechanism across species.
Original Paper
Ha SG, Lee H, Park J, Lee D, Lee GY, Ham S, Kwon S, Park S, Kim SS, Jung Y, Lee J, Sohn J, An SWA, Son HG, Hwang W, Kim HI, Kang E, Kim YK, Lee G, Lee SV
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