Aging Blood Stem Cells May Be a Hidden Source of Chronic Inflammation
Graded Preliminary — mouse study of SIRT3 in hematopoietic stem cells and aging-related inflammation, not yet tested in people.
Animal study. Findings may not carry over to people, which is why the grade is capped at Preliminary.
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- U.S. Department of Health & Human Services | National Institutes of Health…
In mice, the stem cells that make blood become a driver of the constant, low-level inflammation that comes with age. A mitochondrial protein called SIRT3 normally keeps these cells in check, but it fades over time. Boosting SIRT3 in these stem cells reduced inflammation and even improved memory and movement in older mice. This points to the blood-forming system as a possible target for staying healthier longer.
Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.