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Journal ArticleNature aging·Jul 2026

Aging Blood Stem Cells May Be a Hidden Source of Chronic Inflammation

In mice, the stem cells that make blood become a driver of the constant, low-level inflammation that comes with age. A mitochondrial protein called SIRT3 normally keeps these cells in check, but it fades over time. Boosting SIRT3 in these stem cells reduced inflammation and even improved memory and movement in older mice. This points to the blood-forming system as a possible target for staying healthier longer.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.