Journal ArticlePreprintmedRxiv : the preprint server for health sciences·Jul 2026
Metformin Slowed Frailty and Turned Back Epigenetic Clocks in Two-Year Trial
Key Insight
This study suggests metformin's anti-aging effects depend heavily on how you measure frailty.
Older adults with prediabetes took metformin or a placebo for two years. Those on metformin accumulated fewer health deficits over time, and two DNA-based age clocks in their blood ticked slower. The picture was mixed though: on the classic frailty checklist, metformin looked worse in year one, but only because the drug caused weight loss. It was well tolerated overall.
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