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Journal ArticleNature aging·Graded and published ·Last edited

Regular Exercise May Rewind the Molecular Clock in Aging Muscle

Graded Moderate — cross-sectional multiomics study of muscle in young and older adults with differing fitness, though training was not assigned and outcomes are molecular markers rather than health.

Key Insight

This study suggests sustained physical training may keep aging muscle more youthful.


In older adults, muscle showed lower activity in genes tied to energy production compared to younger people. But in older adults who trained regularly, half of those aging changes were gone. Their muscle looked more like young muscle at the molecular level.

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.