Why 17α-Estradiol Extends Lifespan in Male Mice but Not Females
Graded Preliminary — narrative review of preclinical studies, with the lifespan and metabolic benefits shown so far in male mice rather than in people.
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- Authors received funding from NIH, VA Medical Center, and a reproductive…
17α-estradiol is a quirky cousin of the main estrogen hormone, and in mice it stretches lifespan and improves metabolism only in males. It trims body fat, sharpens insulin sensitivity, and protects the liver, with just mild feminizing effects. Scientists still don't fully know why males benefit and females don't. This is early-stage animal research, not yet ready for humans.
Conflict of Interest Disclosure: Authors received funding from NIH, VA Medical Center, and a reproductive longevity consortium. No commercial conflicts declared.
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