Metformin's Anti-Aging Case: Strong Clues but Still No Proof
Einstufung Moderat — narrative Übersichtsarbeit zu präklinischen, Kohorten- und Studiendaten zu Metformin und Altern, wobei die Humanevidenz meist observational ist und keine Studie bisher Altern selbst prüft.
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This review suggests metformin shows promise against aging but its effects may differ by age.
This review pulls together lab, population, and clinical trial evidence on metformin as a potential aging-slowing drug. At normal doses, metformin seems to flip several key aging switches: boosting cellular cleanup, calming inflammation, and improving energy production. Large population studies link metformin use to lower rates of age-related diseases, even in people without diabetes. However, the review honestly notes that metformin may actually worsen aging in older animals, so the picture is still mixed.
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