Cold thermogenesis

Cold thermogenesis is the body's heat-producing response to cold, comprising shivering thermogenesis in skeletal muscle and non-shivering thermogenesis driven by UCP1-dependent activation of brown and other thermogenic ('beige') adipose depots. Repeated cold stimulation can increase tracer-based glucose uptake by thermogenic adipose tissue in small imaging studies, though this reflects local activity rather than necessarily systemic metabolic improvement. Whether these effects translate into durable, clinically meaningful improvements in body composition or metabolic health remains under investigation.