Hyperbaric oxygen therapy (HBOT)

Hyperbaric oxygen therapy delivers 100% oxygen at pressures typically of 2.0–2.4 atmospheres absolute (with the clinical threshold for HBOT generally defined as at least 1.4 ATA) inside a pressurised chamber, dramatically increasing dissolved oxygen in plasma. It is an established treatment for decompression sickness, carbon monoxide poisoning, and selected non-healing wounds. Off-label longevity uses (telomere length, cognition, anti-ageing) rely on small trials with methodological limits; current evidence does not support routine use for healthy ageing.