What is the Longevity Research Library?

The Longevity Germany Research Library curates recent peer-reviewed studies on longevity, nutrition, exercise, sleep, and supplements. Each study is rated by evidence strength: Strong, Moderate, or Preliminary.

How are evidence levels determined?

Evidence levels are based on study type (meta-analysis, RCT, cohort study), sample size, journal impact factor, and reproducibility of findings.

74 studies

Research Library

Peer-reviewed papers from top journals, summarized and graded by evidence strength. Updated Mon, Wed & Fri.

8/74

Apr 19–25, 2026

Cardio vs. Weights for Type 2 Diabetes: Different Wins for Each

In adults with Type 2 diabetes, cardio and resistance training help in different ways. Aerobic exercise was best for boosting adiponectin and lowering leptin, two hormones tied to fat regulation. Resistance training showed bigger drops in inflammatory markers like TNF-alpha and IL-6, especially in younger or overweight people. The authors caution these results are hypothesis-generating, not firm exercise prescriptions.

Diabetes, obesity & metabolism·Moderate·Apr 24, 2026

Mar 22–28, 2026

Centenarians Show a Distinct Metabolic Profile Tied to Bile Acids and NAD+

People who live past 100 have a unique metabolic fingerprint. In a study of 213 participants from the New England Centenarian Study, extremely long-lived individuals had higher levels of certain bile acids and lower levels of bilirubin compared to younger controls. Higher bile acid and steroid levels were linked to lower mortality risk. The researchers also built a "metabolomic clock" that estimates biological age, and deviations from it predicted death risk.

GeroScience·Moderate·Mar 27, 2026

Mar 15–21, 2026

Two Opposing Brain Fuel Patterns May Predict Who Keeps Their Cognition With Age

Brain white matter (the wiring that connects brain regions) uses glucose differently depending on where you look. In over 3,000 participants across two studies, higher glucose use in expected areas like the corpus callosum linked to better thinking skills. But higher glucose use in unusual areas like the corona radiata linked to worse cognition, likely a sign the brain is compensating. Over time, people with strong "normal" metabolism and low "compensatory" metabolism declined more slowly.

Nature communications·Moderate·Mar 19, 2026

How Excess Fructose May Damage Far More Than Just Your Liver

This review pulls together evidence showing fructose does more than add calories. It triggers a chain reaction: uric acid buildup, mitochondrial stress, and fat storage signals that affect the liver, kidneys, pancreas, gut, heart, lungs, and brain. The damage traces back to how fructose is processed differently than glucose, depleting cellular energy and driving inflammation. Animal and human studies both point to fructose overload as a metabolic disruptor across nearly every organ system.

Frontiers in bioscience (Elite edition)·Moderate·Mar 17, 2026

Mar 8–14, 2026

Blood Proteins May Reveal Two Critical Windows for Frailty Around Ages 50 and 63

A study of over 50,000 UK Biobank participants found 1,339 blood proteins linked to frailty. Researchers built a "proteomic frailty score" that predicted risk for 199 diseases and responded to 84 modifiable risk factors. The most striking finding: frailty-related protein changes showed two distinct peaks, around ages 50 and 63. These windows could represent key moments when biological aging accelerates.

Cell metabolism·Moderate·Mar 16, 2026

Caloric Restriction Slows Aging Most in the Heart and Metabolism

Cutting calories doesn't slow aging evenly across all organs. In a two-year trial, 185 adults were randomly assigned to caloric restriction or normal eating. The caloric restriction group aged about one year less in their cardiovascular and metabolic systems over 24 months. Kidney aging, however, didn't budge, and liver aging only slowed modestly at the two-year mark.

Clinical nutrition (Edinburgh, Scotland)·Strong·Mar 14, 2026

Vitamin C May Slow Primate Aging by Blocking Iron-Driven Cell Damage

As primates age, iron builds up in tissues and fuels a chain reaction of fat damage in cells. Researchers call this process "ferro-aging" and found that a specific enzyme (ACSL4) drives it. When aged monkeys received vitamin C for over 40 months, it directly blocked that enzyme. The result was reduced tissue damage, better brain and metabolic function, and biological age clocks that ticked backward across multiple organs.

Cell metabolism·Moderate·Mar 11, 2026

Mar 1–7, 2026

A Newly Found Enzyme Breaks Down NAD+ Inside Mitochondria

Scientists identified a mitochondrial enzyme called SelO that breaks NAD+ into NMN and AMP. This reaction ramps up when mitochondria are working hard, essentially acting as a brake to prevent metabolic overload. It also plays a direct role in fat burning by linking up with fat oxidation enzymes. The mechanism is conserved from bacteria to mammals, suggesting it's been essential for a very long time.

Cell·Preliminary·Mar 9, 2026

Disclaimer: Research summaries are provided for informational purposes only and do not constitute medical advice. Always consult a qualified healthcare professional before making changes to your health routine.

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